This traditional view currently is under scrutiny. Tubulo-interstitial rejection is a prime example. Consequently, nearly all acute rejection episodes have been classified as ‘cell mediated’. Hence, antibody-mediated rejection episodes frequently remained undiagnosed and unclassified. The difficulties with identifying humoral rejection are due mainly to the lack of typical morphological and immunohistochemical changes characterizing different forms of an antibody response. In particular, the proper identification of humoral rejection episodes after the immediate post-transplantation period causes problems. ![]() However, all current classification schemes of renal allograft rejection have major shortcomings. They form the backbone for the clinical decision making, outcome studies and multicentre analyses of the efficacy of new immunosuppressive drugs. ![]() Over the past decades, morphological criteria of acute and chronic rejection have been defined, and classification schemes of rejection have been introduced, such as the CCTT and the Banff schemes. The gold standard for the diagnosis of rejection and for guiding patient management is the histological evaluation of a renal allograft biopsy. Antibodies, C4d, diagnosis, rejection, therapy Background
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |